- PII
- 10.31857/S0033994624040089-1
- DOI
- 10.31857/S0033994624040089
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 60 / Issue number 4
- Pages
- 130-136
- Abstract
- Nonea rossica Steven – a perennial herbaceous plant of the Boraginaceae family and herbal drug preparations obtained from it are of interest as they exhibit indirect anticoagulant properties, antimicrobial and antifungal activity. At the same time, it is known that Boraginaceae species contain pyrrolizidine alkaloids that have a hepatotoxic effect, which makes it difficult to use preparations made from these plants. Along with alkaloids, the toxicity of herbal preparations is also determined by toxic trace elements. The objective of the research was to study the toxic components in the above-ground parts of N. rossica. The composition and content of alkaloids were determined by HPLC. Quantitative determination of trace element content was carried out using inductively coupled plasma mass spectrometry. The analyses determined the presence of pyrrolizidine enantiomers intermedine and lycopsamine and their derivatives; their total content in plant raw materials was less than 20000 μg/kg. The content of such toxic elements as As, Cd, Pb, Hg, Be, Sr, Sb, Tl, and U does not exceed legally permissible concentrations.
- Keywords
- Nonea rossica Boraginaceae токсичные компоненты интермедин ликопсамин микроэлементы
- Date of publication
- 15.12.2024
- Year of publication
- 2024
- Number of purchasers
- 0
- Views
- 53
References
- 1. Долганова О. М., Величко В. В., Карташова М. Е., Ершов К. И., Круглов Д. С. 2023. Антикоагулянтная активность травы нонеи русской (Nonea rossica Steven). — Journal of Siberian Medical Sciences. 7(4): 68–76. https://doi.org/10.31549/2542-1174-2023-7-4-68-76
- 2. Величко В. В., Карташова М. Е., Кучерова С. Д., Круглов Д. С., Бурова Л. Г., Евстропов А. Н. 2023. Фитохимическая характеристика и антимикробные свойства экстрактов Nonea rossica (Boraginaceae). — Раст. ресурсы. 59(3): 297–305. https://doi.org/10.31857/S0033994623030068
- 3. El-Shazly A., Wink M. 2014. Diversity of pyrrolizidine alkaloids in the boraginaceae structures, distribution, and biological properties. — Diversity. 6(2): 188–282. https://doi.org/10.3390/d6020188
- 4. Cooper R. A., Huxtable R. J. 1999. The relationship between reactivity of metabolites of pyrrolizidine alkaloids and extrahepatic toxicity. — Proc. West Pharmacol. Soc. 42: 13–16.
- 5. ОФС.1.5.3.0009 Определение содержания тяжелых металлов и мышьяка в лекарственном растительном сырье и лекарственных растительных препаратах. Государственная фармакопея Российской Федерации. XV изд. М.; 2023. https://pharmacopoeia.regmed.ru/pharmacopoeia/izdanie-15/1/1-5/1-5-1/opredelenie-soderzhaniya-tyazhyelykh-metallov-i-myshyaka-v-lekarstvennom-rastitelnom-syre-i-lekarstv/
- 6. Ребров В. Г., Громова О. А. 2008. Витамины, макро- и микроэлементы. М. 960 с.
- 7. Kashchenko N. I., Olennikov D. N., Chirikova N. K. 2023. Phenolic compounds and pyrrolizidine alkaloids of two north bluebells: Mertensia stylosa and Mertensia serrulate. — Applied Sciences. 13(5): 3266. https://doi.org/10.3390/app13053266
- 8. Никитин В. И. 2017. Первичная статистическая обработка экспериментальных данных. Самара. 80 с.
- 9. Беленький М. Л. 1963. Элементы количественной оценки фармакологического эффекта. Л. 151 с.
- 10. СанПиН 1.2.3685-21 «Гигиенические нормативы и требования к обеспечению безопасности и (или) безвредности для человека факторов среды обитания» https://docs.cntd.ru/document/573500115
- 11. Никонов Г. К., Мануйлов Б. М. 2005. Основы современной фитотерапии. М. 520 с.
- 12. Wang Z., Qiao L., Zheng Q., Han H., Li Z., Zhang X., Chen H. 2022. Combined Hepatotoxicity and toxicity mechanism of intermedine and lycopsamine. — Toxins. 14(9): 633. https://doi.org/10.3390/toxins14090633
- 13. Wang Z., Han H., Wang C., Zheng Q., Chen H., Zhang X., Hou R. 2021. Hepatotoxicity of pyrrolizidine alkaloid compound intermedine: comparison with other pyrrolizidine alkaloids and its toxicological mechanism. — Toxins. 13(12): 849. https://doi.org/10.3390/toxins13120849
